Leishmania infantum exploits the anti-ferroptosis effects of Nrf2 to escape cell death in macrophages

Leishmania infantum exploits the anti-ferroptosis effects of Nrf2 to escape cell death in macrophages

Blog Article

Summary: Macrophages are major host cells for the protozoan Leishmania parasite.Depending on their activation state, they either contribute to the detection and elimination of R/C Construction Leishmania spp.or promote parasite resilience.Here, we report that the activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) in macrophages plays a pivotal role in the progression of Leishmania infantum infection by controlling inflammation and redox balance of macrophages.We also highlight the involvement of the NOX2/reactive oxygen species (ROS) axis in early Nrf2 activation and, subsequently, prostaglandin E2 (PGE2)/EP2r signaling in the sustenance of Nrf2 activation upon infection.

Moreover, we establish a ferroptosis-like process within macrophages as a cell death program of L.infantum and the protective effect of Nrf2 in macrophages against L.infantum death.Altogether, these results Grill Pans identify Nrf2 as a critical factor for the susceptibility of L.infantum infection, highlighting Nrf2 as a promising pharmacological target for the development of therapeutic approaches for the treatment of visceral leishmaniasis.